/* ═══════════════════════════════════════════════════════════════
   TAVNEOS ADR & PHARMACOVIGILANCE REPORT — STYLES
   Palette: Deep Navy + Crimson Medical + Alpine Frost
   Typography: Cormorant Garamond (display) + Bricolage Grotesque (body)
═══════════════════════════════════════════════════════════════ */

:root {
  /* Core palette */
  --navy-950:   #020b18;
  --navy-900:   #050d1a;
  --navy-800:   #0a1628;
  --navy-700:   #0f2040;
  --navy-600:   #162a52;
  --navy-500:   #1e3a6e;

  --crimson-900: #4a0a0a;
  --crimson-800: #7b1818;
  --crimson-700: #922b21;
  --crimson-600: #c0392b;
  --crimson-500: #e74c3c;
  --crimson-400: #f1948a;
  --crimson-300: #fadbd8;

  --frost-100:  #f0f5fb;
  --frost-200:  #dce8f5;
  --frost-300:  #b8d0e8;
  --frost-400:  #8ab0d0;
  --frost-500:  #5a8fb8;

  --amber-500:  #f39c12;
  --amber-400:  #f5b942;
  --green-500:  #27ae60;
  --purple-500: #8e44ad;

  --text-primary:   #e8e4df;
  --text-secondary: #a8b8c8;
  --text-muted:     #5a7080;
  --text-dark:      #1a2535;
  --text-dark-sec:  #3a4a5a;

  --border-dark:  rgba(255,255,255,0.07);
  --border-light: rgba(0,0,0,0.08);

  /* Typography */
  --font-display: 'Cormorant Garamond', Georgia, serif;
  --font-body:    'Bricolage Grotesque', system-ui, sans-serif;
  --font-mono:    'Space Mono', monospace;

  /* Spacing */
  --section-pad: 100px;
  --container:   1200px;
}

/* ── RESET ── */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }
html { scroll-behavior: smooth; font-size: 16px; }
body {
  font-family: var(--font-body);
  background: var(--navy-900);
  color: var(--text-primary);
  line-height: 1.65;
  overflow-x: hidden;
  -webkit-font-smoothing: antialiased;
}
a { color: inherit; text-decoration: none; }
ul { list-style: none; }
img { max-width: 100%; display: block; }

/* ── CONTAINER ── */
.container {
  max-width: var(--container);
  margin: 0 auto;
  padding: 0 40px;
}

/* ══════════════════════════════════════════════════════════════
   NAVIGATION
══════════════════════════════════════════════════════════════ */
.nav {
  position: fixed;
  top: 0; left: 0; right: 0;
  z-index: 100;
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 18px 48px;
  background: rgba(5, 13, 26, 0.85);
  backdrop-filter: blur(20px);
  border-bottom: 1px solid var(--border-dark);
}
.nav__brand {
  display: flex;
  align-items: center;
  gap: 14px;
}
.nav__pill {
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 2px;
  color: var(--crimson-500);
  border: 1px solid var(--crimson-700);
  padding: 4px 10px;
  border-radius: 2px;
  text-transform: uppercase;
}
.nav__year {
  font-family: var(--font-mono);
  font-size: 11px;
  color: var(--text-muted);
  letter-spacing: 1px;
}
.nav__links {
  display: flex;
  gap: 32px;
}
.nav__links a {
  font-family: var(--font-body);
  font-size: 12px;
  font-weight: 500;
  letter-spacing: 0.5px;
  color: var(--text-secondary);
  text-transform: uppercase;
  transition: color 0.2s;
}
.nav__links a:hover { color: var(--text-primary); }

/* ══════════════════════════════════════════════════════════════
   HERO
══════════════════════════════════════════════════════════════ */
.hero {
  position: relative;
  min-height: 100vh;
  display: flex;
  flex-direction: column;
  background: var(--navy-950);
  overflow: hidden;
  padding-top: 80px;
}

/* Grid background */
.hero__bg-grid {
  position: absolute;
  inset: 0;
  background-image:
    linear-gradient(rgba(74,144,217,0.04) 1px, transparent 1px),
    linear-gradient(90deg, rgba(74,144,217,0.04) 1px, transparent 1px);
  background-size: 60px 60px;
  pointer-events: none;
}

/* Particles canvas */
.hero__particles {
  position: absolute;
  inset: 0;
  pointer-events: none;
}

/* Ambient glow */
.hero::before {
  content: '';
  position: absolute;
  top: -200px; left: -200px;
  width: 700px; height: 700px;
  background: radial-gradient(circle, rgba(192,57,43,0.12) 0%, transparent 70%);
  pointer-events: none;
}
.hero::after {
  content: '';
  position: absolute;
  bottom: -100px; right: -100px;
  width: 500px; height: 500px;
  background: radial-gradient(circle, rgba(30,58,110,0.3) 0%, transparent 70%);
  pointer-events: none;
}

.hero__content {
  position: relative;
  z-index: 2;
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 60px;
  align-items: center;
  max-width: var(--container);
  margin: 0 auto;
  padding: 80px 40px 60px;
  width: 100%;
}

/* Hero left */
.hero__badge {
  margin-bottom: 28px;
}
.badge--alert {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 2px;
  color: var(--amber-500);
  border: 1px solid rgba(243,156,18,0.4);
  background: rgba(243,156,18,0.08);
  padding: 6px 14px;
  border-radius: 2px;
  animation: alertPulse 2.5s ease-in-out infinite;
}
@keyframes alertPulse {
  0%, 100% { border-color: rgba(243,156,18,0.4); box-shadow: none; }
  50% { border-color: rgba(243,156,18,0.8); box-shadow: 0 0 12px rgba(243,156,18,0.2); }
}

.hero__title {
  display: flex;
  flex-direction: column;
  gap: 4px;
  margin-bottom: 20px;
}
.hero__title--sub {
  font-family: var(--font-mono);
  font-size: 13px;
  letter-spacing: 3px;
  color: var(--frost-400);
  text-transform: uppercase;
}
.hero__title--main {
  font-family: var(--font-display);
  font-size: clamp(52px, 6vw, 80px);
  font-weight: 600;
  line-height: 0.95;
  color: var(--text-primary);
  letter-spacing: -1px;
}
.hero__title--desc {
  font-family: var(--font-display);
  font-size: clamp(22px, 2.5vw, 32px);
  font-weight: 300;
  font-style: italic;
  color: var(--frost-400);
  line-height: 1.3;
  margin-top: 6px;
}

.hero__meta {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 1.5px;
  color: var(--text-muted);
  text-transform: uppercase;
  margin-bottom: 40px;
  padding-bottom: 40px;
  border-bottom: 1px solid var(--border-dark);
}

.hero__stats-row {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 20px;
}
.hero__stat {
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.hero__stat-num {
  font-family: var(--font-display);
  font-size: clamp(28px, 3vw, 42px);
  font-weight: 600;
  color: var(--frost-300);
  line-height: 1;
}
.hero__stat--danger .hero__stat-num { color: var(--crimson-500); }
.hero__stat-label {
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 1px;
  color: var(--text-muted);
  text-transform: uppercase;
  line-height: 1.4;
}

/* Hero right — liver illustration */
.liver-wrap {
  position: relative;
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: 16px;
}
.liver-svg {
  width: 100%;
  max-width: 520px;
  border-radius: 4px;
  border: 1px solid rgba(74,144,217,0.1);
  box-shadow:
    0 0 60px rgba(192,57,43,0.15),
    0 0 120px rgba(5,13,26,0.8),
    inset 0 0 40px rgba(5,13,26,0.5);
}

/* Pulse animations for SVG elements */
.pulse-ring {
  animation: pulseRing 2s ease-in-out infinite;
  transform-origin: center;
}
.pulse-ring-slow {
  animation: pulseRing 3s ease-in-out infinite;
  transform-origin: center;
}
@keyframes pulseRing {
  0%, 100% { opacity: 0.3; r: 8; }
  50% { opacity: 0.7; r: 14; }
}

.molecule {
  animation: moleculeFloat 4s ease-in-out infinite;
  transform-origin: center;
}
@keyframes moleculeFloat {
  0%, 100% { transform: translate(390px, 80px) translateY(0); }
  50% { transform: translate(390px, 80px) translateY(-6px); }
}

.liver-caption {
  display: flex;
  align-items: center;
  gap: 8px;
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 1px;
  color: var(--text-muted);
  text-transform: uppercase;
}
.liver-caption__dot {
  width: 6px; height: 6px;
  border-radius: 50%;
  flex-shrink: 0;
}
.liver-caption__dot--danger {
  background: var(--crimson-500);
  box-shadow: 0 0 6px var(--crimson-500);
  animation: dotPulse 1.5s ease-in-out infinite;
}
@keyframes dotPulse {
  0%, 100% { opacity: 1; }
  50% { opacity: 0.4; }
}

/* Scroll hint */
.hero__scroll-hint {
  position: relative;
  z-index: 2;
  display: flex;
  flex-direction: column;
  align-items: center;
  gap: 10px;
  padding-bottom: 40px;
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 2px;
  color: var(--text-muted);
  text-transform: uppercase;
}
.scroll-arrow {
  width: 1px;
  height: 40px;
  background: linear-gradient(to bottom, var(--text-muted), transparent);
  animation: scrollArrow 2s ease-in-out infinite;
}
@keyframes scrollArrow {
  0% { transform: scaleY(0); transform-origin: top; }
  50% { transform: scaleY(1); transform-origin: top; }
  51% { transform: scaleY(1); transform-origin: bottom; }
  100% { transform: scaleY(0); transform-origin: bottom; }
}

/* ══════════════════════════════════════════════════════════════
   SECTIONS
══════════════════════════════════════════════════════════════ */
.section {
  padding: var(--section-pad) 0;
}
.section--dark {
  background: var(--navy-900);
}
.section--light {
  background: var(--frost-100);
  color: var(--text-dark);
}
.section--light .text-secondary { color: var(--text-dark-sec); }

.section__header {
  margin-bottom: 60px;
}
.section__tag {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 2.5px;
  color: var(--frost-400);
  text-transform: uppercase;
  margin-bottom: 16px;
  padding-bottom: 16px;
  border-bottom: 1px solid var(--border-dark);
}
.section--light .section__tag {
  color: var(--navy-600);
  border-bottom-color: var(--border-light);
}
.section__tag--danger { color: var(--crimson-500) !important; }
.section__tag--warning { color: var(--amber-500) !important; }

.section__title {
  font-family: var(--font-display);
  font-size: clamp(36px, 4vw, 56px);
  font-weight: 500;
  line-height: 1.1;
  letter-spacing: -0.5px;
  color: var(--text-primary);
}
.section--light .section__title { color: var(--text-dark); }

.section__subtitle {
  margin-top: 16px;
  font-size: 16px;
  color: var(--text-secondary);
  max-width: 640px;
  line-height: 1.7;
}
.section--light .section__subtitle { color: var(--text-dark-sec); }

.subsection-title {
  font-family: var(--font-display);
  font-size: 24px;
  font-weight: 500;
  margin-bottom: 24px;
  color: var(--text-primary);
}
.section--light .subsection-title { color: var(--text-dark); }

/* ══════════════════════════════════════════════════════════════
   REVEAL ANIMATIONS
══════════════════════════════════════════════════════════════ */
.reveal {
  opacity: 0;
  transform: translateY(30px);
  transition: opacity 0.7s ease, transform 0.7s ease;
}
.reveal.visible {
  opacity: 1;
  transform: translateY(0);
}
.reveal--delay  { transition-delay: 0.15s; }
.reveal--delay2 { transition-delay: 0.3s; }
.reveal--delay3 { transition-delay: 0.45s; }

/* ══════════════════════════════════════════════════════════════
   OVERVIEW CARDS
══════════════════════════════════════════════════════════════ */
.overview-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 24px;
}
.overview-card {
  background: rgba(255,255,255,0.03);
  border: 1px solid var(--border-dark);
  border-radius: 4px;
  padding: 32px 28px;
  transition: border-color 0.3s, background 0.3s, transform 0.3s;
}
.overview-card:hover {
  border-color: rgba(74,144,217,0.3);
  background: rgba(74,144,217,0.05);
  transform: translateY(-4px);
}
.overview-card__icon {
  font-size: 24px;
  margin-bottom: 16px;
  color: var(--frost-400);
}
.overview-card h3 {
  font-family: var(--font-display);
  font-size: 20px;
  font-weight: 500;
  margin-bottom: 12px;
  color: var(--text-primary);
}
.overview-card p {
  font-size: 14px;
  color: var(--text-secondary);
  line-height: 1.7;
}
.overview-card p strong { color: var(--frost-300); }

/* ══════════════════════════════════════════════════════════════
   DILI SECTION
══════════════════════════════════════════════════════════════ */
.dili-hero {
  margin-bottom: 48px;
}
.dili-hero__alert {
  display: flex;
  gap: 24px;
  align-items: flex-start;
  background: rgba(192,57,43,0.08);
  border: 1px solid rgba(192,57,43,0.3);
  border-left: 4px solid var(--crimson-600);
  border-radius: 4px;
  padding: 28px 32px;
}
.dili-hero__alert-icon {
  font-size: 28px;
  flex-shrink: 0;
  margin-top: 2px;
}
.dili-hero__alert-text strong {
  display: block;
  font-size: 15px;
  font-weight: 600;
  color: var(--text-dark);
  margin-bottom: 8px;
}
.dili-hero__alert-text p {
  font-size: 14px;
  color: var(--text-dark-sec);
  line-height: 1.7;
}

.dili-stats {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 20px;
  margin-bottom: 60px;
}
.dili-stat-card {
  background: white;
  border-radius: 4px;
  padding: 28px 24px;
  box-shadow: 0 2px 20px rgba(0,0,0,0.06);
  border-top: 3px solid transparent;
}
.dili-stat-card--critical { border-top-color: var(--crimson-600); }
.dili-stat-card--serious  { border-top-color: var(--crimson-500); }
.dili-stat-card--hospital { border-top-color: var(--amber-500); }
.dili-stat-card--fatal    { border-top-color: var(--crimson-800); }

.dili-stat-card__num {
  font-family: var(--font-display);
  font-size: 52px;
  font-weight: 600;
  line-height: 1;
  color: var(--text-dark);
  margin-bottom: 8px;
}
.dili-stat-card--fatal .dili-stat-card__num { color: var(--crimson-700); }
.dili-stat-card__label {
  font-size: 13px;
  color: var(--text-dark-sec);
  margin-bottom: 16px;
  font-weight: 500;
}
.dili-stat-card__bar {
  height: 4px;
  background: var(--frost-200);
  border-radius: 2px;
  overflow: hidden;
}
.dili-stat-card__fill {
  height: 100%;
  border-radius: 2px;
  background: var(--crimson-600);
  width: 0;
  transition: width 1.2s cubic-bezier(0.4,0,0.2,1);
}
.dili-stat-card--hospital .dili-stat-card__fill { background: var(--amber-500); }
.dili-stat-card--fatal    .dili-stat-card__fill { background: var(--crimson-800); }

.two-col {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 48px;
  align-items: start;
}

/* ADR List */
.adr-list {
  display: flex;
  flex-direction: column;
  gap: 10px;
}
.adr-item {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 14px 18px;
  background: white;
  border-radius: 4px;
  border-left: 3px solid transparent;
  box-shadow: 0 1px 8px rgba(0,0,0,0.05);
  transition: transform 0.2s;
}
.adr-item:hover { transform: translateX(4px); }
.adr-item--moderate { border-left-color: var(--amber-500); }
.adr-item--severe   { border-left-color: var(--crimson-500); }
.adr-item--critical { border-left-color: var(--crimson-700); background: rgba(192,57,43,0.04); }
.adr-item__name {
  font-size: 14px;
  font-weight: 500;
  color: var(--text-dark);
}
.adr-item__severity {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.5px;
  padding: 3px 8px;
  border-radius: 2px;
}
.adr-item__severity--moderate { background: rgba(243,156,18,0.12); color: #b7770d; }
.adr-item__severity--severe   { background: rgba(192,57,43,0.1);  color: var(--crimson-700); }
.adr-item__severity--critical { background: rgba(122,10,10,0.12); color: var(--crimson-800); font-weight: 700; }

/* VBDS Card */
.vbds-card {
  background: white;
  border-radius: 4px;
  overflow: hidden;
  box-shadow: 0 4px 24px rgba(0,0,0,0.08);
}
.vbds-card__header {
  background: var(--crimson-700);
  color: white;
  font-family: var(--font-display);
  font-size: 20px;
  font-weight: 500;
  padding: 18px 24px;
  letter-spacing: 0.3px;
}
.vbds-card p {
  padding: 20px 24px;
  font-size: 14px;
  color: var(--text-dark-sec);
  line-height: 1.7;
  border-bottom: 1px solid var(--frost-200);
}
.vbds-outcomes {
  padding: 16px 24px;
  display: flex;
  flex-direction: column;
  gap: 10px;
}
.vbds-outcome {
  display: flex;
  align-items: center;
  gap: 12px;
  font-size: 14px;
  color: var(--text-dark-sec);
}
.vbds-outcome--fatal { color: var(--crimson-700); font-weight: 600; }
.vbds-outcome__icon { color: var(--crimson-500); font-weight: 700; }
.vbds-card__footer {
  background: rgba(192,57,43,0.06);
  border-top: 1px solid rgba(192,57,43,0.15);
  padding: 14px 24px;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.5px;
  color: var(--crimson-700);
  text-transform: uppercase;
}

/* ══════════════════════════════════════════════════════════════
   JAPAN SECTION
══════════════════════════════════════════════════════════════ */
.japan-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 24px;
  margin-bottom: 60px;
}
.japan-stat {
  background: rgba(255,255,255,0.03);
  border: 1px solid var(--border-dark);
  border-radius: 4px;
  padding: 32px 24px;
  text-align: center;
  transition: border-color 0.3s, transform 0.3s;
}
.japan-stat:hover {
  border-color: rgba(243,156,18,0.3);
  transform: translateY(-4px);
}
.japan-stat__flag {
  font-size: 32px;
  margin-bottom: 16px;
}
.japan-stat__num {
  font-family: var(--font-display);
  font-size: 36px;
  font-weight: 600;
  color: var(--amber-400);
  margin-bottom: 8px;
  line-height: 1;
}
.japan-stat__label {
  font-size: 13px;
  color: var(--text-secondary);
  line-height: 1.4;
}

/* Risk factors */
.risk-factors { }
.risk-grid {
  display: grid;
  grid-template-columns: repeat(5, 1fr);
  gap: 20px;
}
.risk-card {
  background: rgba(255,255,255,0.03);
  border: 1px solid var(--border-dark);
  border-radius: 4px;
  padding: 24px 20px;
  transition: border-color 0.3s, background 0.3s;
}
.risk-card:hover {
  border-color: rgba(243,156,18,0.3);
  background: rgba(243,156,18,0.04);
}
.risk-card__icon {
  font-size: 24px;
  margin-bottom: 12px;
}
.risk-card__title {
  font-size: 13px;
  font-weight: 600;
  color: var(--amber-400);
  margin-bottom: 8px;
  line-height: 1.3;
}
.risk-card__desc {
  font-size: 12px;
  color: var(--text-secondary);
  line-height: 1.6;
}

/* ══════════════════════════════════════════════════════════════
   FAERS SECTION
══════════════════════════════════════════════════════════════ */
.faers-signals {
  margin-bottom: 60px;
}
.signal-bars {
  display: flex;
  flex-direction: column;
  gap: 16px;
}
.signal-bar {
  display: grid;
  grid-template-columns: 240px 1fr 100px;
  align-items: center;
  gap: 20px;
}
.signal-bar__label {
  font-size: 14px;
  font-weight: 500;
  color: var(--text-dark);
  text-align: right;
}
.signal-bar__track {
  height: 10px;
  background: var(--frost-200);
  border-radius: 5px;
  overflow: hidden;
}
.signal-bar__fill {
  height: 100%;
  border-radius: 5px;
  width: 0;
  transition: width 1.4s cubic-bezier(0.4,0,0.2,1);
}
.signal-bar__fill--critical { background: linear-gradient(90deg, var(--crimson-700), var(--crimson-500)); }
.signal-bar__fill--severe   { background: linear-gradient(90deg, var(--crimson-600), var(--crimson-400)); }
.signal-bar__fill--moderate { background: linear-gradient(90deg, var(--amber-500), var(--amber-400)); }
.signal-bar__value {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.5px;
  color: var(--text-dark-sec);
}

/* ADR Table */
.adr-table-wrap { }
.adr-table {
  width: 100%;
  border-collapse: collapse;
  background: white;
  border-radius: 4px;
  overflow: hidden;
  box-shadow: 0 2px 20px rgba(0,0,0,0.06);
}
.adr-table thead tr {
  background: var(--navy-800);
}
.adr-table thead th {
  padding: 16px 20px;
  text-align: left;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 1.5px;
  color: var(--frost-300);
  text-transform: uppercase;
  font-weight: 400;
}
.adr-table tbody tr {
  border-bottom: 1px solid var(--frost-200);
  transition: background 0.2s;
}
.adr-table tbody tr:hover { background: var(--frost-100); }
.adr-table tbody tr:last-child { border-bottom: none; }
.adr-table tbody td {
  padding: 14px 20px;
  font-size: 14px;
  color: var(--text-dark);
}
.adr-table__highlight {
  background: rgba(192,57,43,0.04) !important;
}
.adr-table__highlight td { font-weight: 500; }

.sev {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 0.5px;
  padding: 3px 8px;
  border-radius: 2px;
}
.sev--mild     { background: rgba(39,174,96,0.1);  color: #1e8449; }
.sev--moderate { background: rgba(243,156,18,0.12); color: #b7770d; }
.sev--severe   { background: rgba(192,57,43,0.1);  color: var(--crimson-700); }
.sev--critical { background: rgba(122,10,10,0.12); color: var(--crimson-800); font-weight: 700; }

/* ══════════════════════════════════════════════════════════════
   REGULATORY TIMELINE
══════════════════════════════════════════════════════════════ */
.reg-timeline {
  display: flex;
  flex-direction: column;
  gap: 0;
  margin-bottom: 48px;
  padding-left: 40px;
}
.reg-event {
  display: grid;
  grid-template-columns: 40px 1fr;
  gap: 32px;
  position: relative;
}
.reg-event__marker {
  display: flex;
  flex-direction: column;
  align-items: center;
  position: relative;
  margin-left: -40px;
}
.reg-event__dot {
  width: 14px; height: 14px;
  border-radius: 50%;
  background: var(--crimson-500);
  border: 2px solid var(--navy-900);
  box-shadow: 0 0 10px rgba(192,57,43,0.5);
  flex-shrink: 0;
  margin-top: 4px;
  z-index: 1;
}
.reg-event__dot--ema   { background: var(--frost-400); box-shadow: 0 0 10px rgba(90,143,184,0.5); }
.reg-event__dot--japan { background: var(--amber-500); box-shadow: 0 0 10px rgba(243,156,18,0.5); }
.reg-event__line {
  width: 1px;
  flex: 1;
  background: var(--border-dark);
  min-height: 40px;
}
.reg-event__content {
  padding-bottom: 40px;
}
.reg-event__agency {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 2px;
  color: var(--text-muted);
  text-transform: uppercase;
  margin-bottom: 4px;
}
.reg-event__date {
  font-family: var(--font-mono);
  font-size: 11px;
  color: var(--frost-400);
  margin-bottom: 10px;
}
.reg-event__content h4 {
  font-family: var(--font-display);
  font-size: 22px;
  font-weight: 500;
  color: var(--text-primary);
  margin-bottom: 10px;
}
.reg-event__content p {
  font-size: 14px;
  color: var(--text-secondary);
  line-height: 1.7;
  max-width: 680px;
  margin-bottom: 14px;
}
.reg-event__content p strong { color: var(--text-primary); }
.reg-event__status {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 1px;
  padding: 4px 10px;
  border-radius: 2px;
  text-transform: uppercase;
}
.reg-event__status--active  { background: rgba(192,57,43,0.15); color: var(--crimson-400); border: 1px solid rgba(192,57,43,0.3); }
.reg-event__status--issued  { background: rgba(192,57,43,0.1);  color: var(--crimson-400); border: 1px solid rgba(192,57,43,0.2); }
.reg-event__status--ongoing { background: rgba(90,143,184,0.1); color: var(--frost-400);   border: 1px solid rgba(90,143,184,0.3); }
.reg-event__status--resumed { background: rgba(243,156,18,0.1); color: var(--amber-400);   border: 1px solid rgba(243,156,18,0.3); }

/* Amgen statement */
.amgen-statement {
  background: rgba(255,255,255,0.03);
  border: 1px solid var(--border-dark);
  border-left: 3px solid var(--frost-400);
  border-radius: 4px;
  padding: 28px 32px;
}
.amgen-statement__header {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 2px;
  color: var(--frost-400);
  text-transform: uppercase;
  margin-bottom: 14px;
}
.amgen-statement p {
  font-family: var(--font-display);
  font-size: 20px;
  font-style: italic;
  color: var(--text-secondary);
  line-height: 1.6;
  margin-bottom: 16px;
}
.ref-link {
  font-family: var(--font-mono);
  font-size: 11px;
  color: var(--frost-400);
  letter-spacing: 0.5px;
  transition: color 0.2s;
}
.ref-link:hover { color: var(--text-primary); }

/* ══════════════════════════════════════════════════════════════
   MONITORING SECTION
══════════════════════════════════════════════════════════════ */
.monitoring-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 24px;
  margin-bottom: 60px;
}
.monitoring-card {
  background: white;
  border-radius: 4px;
  padding: 28px 24px;
  box-shadow: 0 2px 16px rgba(0,0,0,0.06);
  border-top: 3px solid var(--frost-300);
  transition: transform 0.3s, box-shadow 0.3s;
}
.monitoring-card:hover {
  transform: translateY(-4px);
  box-shadow: 0 8px 32px rgba(0,0,0,0.1);
}
.monitoring-card--primary { border-top-color: var(--navy-600); }
.monitoring-card--alert   { border-top-color: var(--crimson-600); background: rgba(192,57,43,0.02); }
.monitoring-card__step {
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 1px;
  color: var(--text-muted);
  margin-bottom: 12px;
}
.monitoring-card--alert .monitoring-card__step { color: var(--crimson-600); font-size: 18px; }
.monitoring-card h4 {
  font-family: var(--font-display);
  font-size: 20px;
  font-weight: 500;
  color: var(--text-dark);
  margin-bottom: 16px;
}
.monitoring-card ul {
  display: flex;
  flex-direction: column;
  gap: 8px;
}
.monitoring-card li {
  font-size: 13px;
  color: var(--text-dark-sec);
  padding-left: 14px;
  position: relative;
  line-height: 1.5;
}
.monitoring-card li::before {
  content: '—';
  position: absolute;
  left: 0;
  color: var(--frost-400);
  font-size: 11px;
}
.monitoring-card--alert li::before { color: var(--crimson-500); }

/* PV Assessment Table */
.pv-table-wrap { }
.pv-table {
  width: 100%;
  border-collapse: collapse;
  background: white;
  border-radius: 4px;
  overflow: hidden;
  box-shadow: 0 2px 20px rgba(0,0,0,0.06);
}
.pv-table tbody tr {
  border-bottom: 1px solid var(--frost-200);
  transition: background 0.2s;
}
.pv-table tbody tr:hover { background: var(--frost-100); }
.pv-table tbody tr:last-child { border-bottom: none; }
.pv-table__category {
  padding: 16px 24px;
  font-size: 14px;
  font-weight: 600;
  color: var(--text-dark);
  width: 40%;
}
.pv-table td:last-child {
  padding: 16px 24px;
}
.pv-badge {
  display: inline-block;
  font-family: var(--font-mono);
  font-size: 11px;
  letter-spacing: 0.5px;
  padding: 5px 12px;
  border-radius: 2px;
}
.pv-badge--positive { background: rgba(39,174,96,0.1);  color: #1e8449; border: 1px solid rgba(39,174,96,0.2); }
.pv-badge--critical { background: rgba(192,57,43,0.1);  color: var(--crimson-700); border: 1px solid rgba(192,57,43,0.2); }
.pv-badge--active   { background: rgba(192,57,43,0.08); color: var(--crimson-600); border: 1px solid rgba(192,57,43,0.15); }
.pv-badge--ongoing  { background: rgba(90,143,184,0.1); color: var(--navy-600);    border: 1px solid rgba(90,143,184,0.2); }
.pv-badge--warning  { background: rgba(243,156,18,0.1); color: #b7770d;            border: 1px solid rgba(243,156,18,0.2); }
.pv-badge--review   { background: rgba(142,68,173,0.1); color: var(--purple-500);  border: 1px solid rgba(142,68,173,0.2); }

/* ══════════════════════════════════════════════════════════════
   REFERENCES
══════════════════════════════════════════════════════════════ */
.references { }
.ref-grid {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 60px;
}
.ref-group h4 {
  font-family: var(--font-mono);
  font-size: 10px;
  letter-spacing: 2px;
  color: var(--text-muted);
  text-transform: uppercase;
  margin-bottom: 24px;
  padding-bottom: 12px;
  border-bottom: 1px solid var(--border-dark);
}
.ref-item {
  display: flex;
  gap: 20px;
  align-items: flex-start;
  padding: 18px 0;
  border-bottom: 1px solid var(--border-dark);
  transition: opacity 0.2s;
}
.ref-item:hover { opacity: 0.75; }
.ref-item:last-child { border-bottom: none; }
.ref-item__num {
  font-family: var(--font-mono);
  font-size: 11px;
  color: var(--frost-400);
  flex-shrink: 0;
  margin-top: 2px;
}
.ref-item__title {
  font-size: 14px;
  color: var(--text-primary);
  margin-bottom: 4px;
  line-height: 1.4;
}
.ref-item__source {
  font-family: var(--font-mono);
  font-size: 10px;
  color: var(--text-muted);
  letter-spacing: 0.5px;
}

/* ══════════════════════════════════════════════════════════════
   FOOTER
══════════════════════════════════════════════════════════════ */
.footer {
  background: var(--navy-950);
  border-top: 1px solid var(--border-dark);
  padding: 48px 0;
}
.footer__inner {
  display: grid;
  grid-template-columns: 1fr 2fr 1fr;
  gap: 40px;
  align-items: center;
}
.footer__brand {
  display: flex;
  flex-direction: column;
  gap: 6px;
}
.footer__drug {
  font-family: var(--font-display);
  font-size: 20px;
  font-weight: 500;
  color: var(--text-primary);
}
.footer__report {
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 1px;
  color: var(--text-muted);
  text-transform: uppercase;
}
.footer__disclaimer {
  font-size: 12px;
  color: var(--text-muted);
  line-height: 1.6;
  text-align: center;
  padding: 0 20px;
  border-left: 1px solid var(--border-dark);
  border-right: 1px solid var(--border-dark);
}
.footer__copy {
  font-family: var(--font-mono);
  font-size: 9px;
  letter-spacing: 1px;
  color: var(--text-muted);
  text-align: right;
  line-height: 1.6;
}

/* ══════════════════════════════════════════════════════════════
   RESPONSIVE
══════════════════════════════════════════════════════════════ */
@media (max-width: 1100px) {
  .overview-grid    { grid-template-columns: repeat(2, 1fr); }
  .risk-grid        { grid-template-columns: repeat(3, 1fr); }
  .monitoring-grid  { grid-template-columns: repeat(2, 1fr); }
  .hero__stats-row  { grid-template-columns: repeat(2, 1fr); }
}

@media (max-width: 900px) {
  .hero__content    { grid-template-columns: 1fr; }
  .hero__right      { display: none; }
  .dili-stats       { grid-template-columns: repeat(2, 1fr); }
  .japan-grid       { grid-template-columns: repeat(2, 1fr); }
  .two-col          { grid-template-columns: 1fr; }
  .ref-grid         { grid-template-columns: 1fr; }
  .footer__inner    { grid-template-columns: 1fr; text-align: center; }
  .footer__copy     { text-align: center; }
  .footer__disclaimer { border: none; padding: 0; }
  .signal-bar       { grid-template-columns: 1fr; }
  .signal-bar__label { text-align: left; }
  .nav__links       { display: none; }
}

@media (max-width: 600px) {
  .container        { padding: 0 20px; }
  :root             { --section-pad: 60px; }
  .overview-grid    { grid-template-columns: 1fr; }
  .dili-stats       { grid-template-columns: 1fr; }
  .japan-grid       { grid-template-columns: 1fr; }
  .risk-grid        { grid-template-columns: 1fr; }
  .monitoring-grid  { grid-template-columns: 1fr; }
  .hero__stats-row  { grid-template-columns: repeat(2, 1fr); }
}